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pentobarbital will reduce the extent or influence of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Solid or moderate CYP3A4 inducers could boost charge of diazepam elimination; for that reason, efficacy of diazepam may very well be lessened.The use of barbiturates as sedatives from the postoperat